The Wolverines built up a huge lead through a cascade of spin moves, drop steps and hook shots, all from Thome.
Kim Barnes Arico broke a four-game losing streak against Michigan State on Tuesday night.
It took just over five minutes of game time for the Wolverines to build up an 18-4 first quarter lead over the Spartans, who never came back or came close to doing so.
On Tuesday, Michigan State looks to dethrone the sixteenth-ranked Wolverines at Crisler Center.
As Michigan has ascended in the last 10 days, notching program-defining wins at Nebraska and No. 8 Ohio State, so has Hailey Brown.
After allowing a quick five points to start the game, the Wolverines (6-2 Big Ten, 17-4 overall) were locked in.
After Katelynn Flaherty made a 3-pointer put Michigan up two in the third quarter, the Wolverines never let go, winning 84-75.
Deja Church hit three free throws to send Michigan and Nebraska into overtime, and the Wolverines pulled away from there, winning 69-64.
The No. 23 Michigan women’s basketball team escaped Crisler Center with an 84-79 win over Indiana on Wednesday night
Brown started hot, accounting for eight of Michigan’s first 10 points, and she went on to finish with a career-high 23 points, while grabbing eight rebounds.