In a recently published study, University researchers revealed a molecular link between the Epstein-Barr virus the virus that causes mononucleosis and certain forms of breast and lymphatic cancer.

The research documents how the virus interferes with the body"s natural ability to block metastasis, the spread of malignant cancer cells, and is the first such discovery of its kind.

"The link between the Epstein-Barr virus and cancer is well known," explained Chitra Subramanian, a research fellow involved with the study. "It"s the interaction between the viral protein and metastasis-suppressant that has been shown in our research."

Traces of the Epstein-Barr virus are present in over 90 percent of adults, but are usually rendered dormant by the body"s immune system. In the case of immune system deficiency , the virus becomes more likely to facilitate the spread of cancer cells.

In documenting the link between the virus and the spread of cancer, researchers hope the findings will lead to new forms of cancer treatment.

"Understanding this mechanism is potentially useful for developing a rational treatment for EBV-associated cancers," said Murray Cotter, a University graduate student involved with the research. "That"s the main reason the research is important to the general public."

The research was published in the March 2001 issue of Nature Science, and University researchers are already underway with a follow-up study. The new study hopes to map the exact location of the viral infection of the body"s defense protein.

In addition, the researchers are pursuing a treatment for blocking the interaction.

"We"re working with companies that might be able to help us screen for the chemical agents with use as therapeutic agents for treating these types of cancers," said Dr. Erle Robertson, the director of the study.

Other researchers are attempting to strike directly at the spread of the Epstein-Barr virus.

"There are trials underway with vaccines in Europe right now," said Robertson.